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NAR 2026 manuscript: sync M14_discussion.tex with Overleaf edits #314

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samseaver merged 1 commit into from
Oct 6, 2026
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NAR 2026 manuscript: sync M14_discussion.tex with Overleaf edits #314

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4 changes: 3 additions & 1 deletion Papers/NAR_Update_2026/latex/sections/M14_discussion.tex
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\section{Discussion}

Unlike the 2020 release, this update adopts a multi-source policy rather than promoting a single thermodynamic value, publishing four sources, each with their own uncertainty and estimated direction, because the sources may disagree in ways a single value conceals. Grading against experiment enables us to validate the approach: A researcher can take the highest-graded source and knows what the grade means. In being explicit about disagreement between sources, we expect this release to serve the widening range of communities that build on shared biochemistry: genome-scale reconstruction, flux analysis, pathway design and the training of predictive models.
Unlike the 2020 release, this update integrates four thermodynamics sources, each with their own uncertainty and estimated direction, and a layered scheme to arrive at a predicted direction where sources disagree in ways a single source conceals.
We further leverage experimental ground truth data to validate our grading of the recommended direction.
In being explicit about disagreement between sources, we expect this release to serve the widening range of researchers who build on shared biochemistry: genome-scale reconstruction, flux analysis, pathway design and the training of predictive models.