diff --git a/src/attr/_make.py b/src/attr/_make.py
index 793bfd89d..e29bd2b2b 100644
--- a/src/attr/_make.py
+++ b/src/attr/_make.py
@@ -844,9 +844,14 @@ def _patch_original_class(self):
 
         # If we've inherited an attrs __setattr__ and don't write our own,
         # reset it to object's.
-        if not self._wrote_own_setattr and getattr(
-            cls, "__attrs_own_setattr__", False
-        ):
+        has_attrs_own_setattr = False
+        for base_cls in cls.__mro__[1:]:
+            if "__setattr__" in base_cls.__dict__:
+                if base_cls.__dict__.get("__attrs_own_setattr__", False):
+                    has_attrs_own_setattr = True
+                break
+
+        if not self._wrote_own_setattr and has_attrs_own_setattr:
             cls.__attrs_own_setattr__ = False
 
             if not self._has_custom_setattr:
@@ -880,9 +885,12 @@ def _create_slots_class(self):
             cd["__attrs_own_setattr__"] = False
 
             if not self._has_custom_setattr:
-                for base_cls in self._cls.__bases__:
-                    if base_cls.__dict__.get("__attrs_own_setattr__", False):
-                        cd["__setattr__"] = _OBJ_SETATTR
+                for base_cls in self._cls.__mro__[1:]:
+                    if "__setattr__" in base_cls.__dict__:
+                        if base_cls.__dict__.get(
+                            "__attrs_own_setattr__", False
+                        ):
+                            cd["__setattr__"] = _OBJ_SETATTR
                         break
 
         # Traverse the MRO to collect existing slots
diff --git a/tests/test_setattr.py b/tests/test_setattr.py
index f44abf658..ea15d8f9e 100644
--- a/tests/test_setattr.py
+++ b/tests/test_setattr.py
@@ -316,14 +316,10 @@ def __setattr__(self, key, value):
         with pytest.raises(SystemError):
             A().x = 1
 
-    @pytest.mark.xfail(raises=attr.exceptions.FrozenAttributeError)
     def test_slotted_confused(self):
         """
         If we have a in-between non-attrs class, setattr reset detection
-        should still work, but currently doesn't.
-
-        It works with dict classes because we can look the finished class and
-        patch it.  With slotted classes we have to deduce it ourselves.
+        should still work.
         """
 
         @attr.s(slots=True)
@@ -339,6 +335,45 @@ class C(B):
 
         C(1).x = 2
 
+    def test_setattr_inherited_do_not_reset_intermediate_non_attrs(
+        self, slots
+    ):
+        """
+        A user-provided intermediate __setattr__ on a non-attrs class is not reset
+        to object.__setattr__.
+        """
+
+        @attr.s(slots=slots)
+        class A:
+            x: int = attr.ib(on_setattr=setters.frozen)
+
+        class BCustom(A):
+            x: int
+
+            def __setattr__(self, name, value):
+                object.__setattr__(self, name, value * 2)
+
+        class BPlain(A):
+            x: int
+
+        @attr.s(slots=slots)
+        class CFromCustom(BCustom):
+            x: int = attr.ib()
+
+        @attr.s(slots=slots)
+        class CFromPlain(BPlain):
+            x: int = attr.ib()
+
+        # CFromPlain should reset to object.__setattr__ and mutate normally
+        c_plain = CFromPlain(1)
+        c_plain.x = 2
+        assert c_plain.x == 2
+
+        # CFromCustom should respect and call BCustom.__setattr__
+        c_custom = CFromCustom(1)
+        c_custom.x = 2
+        assert c_custom.x == 4
+
     def test_setattr_auto_detect_if_no_custom_setattr(self, slots):
         """
         It's possible to remove the on_setattr hook from an attribute and