diff --git a/CHANGES/+cancel-blob-upload.feature b/CHANGES/+cancel-blob-upload.feature
new file mode 100644
index 000000000..43e419df8
--- /dev/null
+++ b/CHANGES/+cancel-blob-upload.feature
@@ -0,0 +1 @@
+Added support for cancelling blob uploads via `DELETE /v2/<name>/blobs/uploads/<uuid>`.
diff --git a/pulp_container/app/exceptions.py b/pulp_container/app/exceptions.py
index 0c10267e3..d8946477d 100644
--- a/pulp_container/app/exceptions.py
+++ b/pulp_container/app/exceptions.py
@@ -90,6 +90,24 @@ def __init__(self, digest):
         )
 
 
+class BlobUploadUnknown(NotFound):
+    """Exception to render a 404 with the code 'BLOB_UPLOAD_UNKNOWN'"""
+
+    def __init__(self, uuid):
+        """Initialize the exception with the upload uuid."""
+        super().__init__(
+            detail={
+                "errors": [
+                    {
+                        "code": "BLOB_UPLOAD_UNKNOWN",
+                        "message": "blob upload unknown to registry",
+                        "detail": {"uuid": uuid},
+                    }
+                ]
+            }
+        )
+
+
 class ManifestNotFound(NotFound):
     """Exception to render a 404 with the code 'MANIFEST_UNKNOWN'"""
 
diff --git a/pulp_container/app/registry_api.py b/pulp_container/app/registry_api.py
index dca3edbba..289eb4356 100644
--- a/pulp_container/app/registry_api.py
+++ b/pulp_container/app/registry_api.py
@@ -66,6 +66,7 @@
     BadGateway,
     BlobInvalid,
     BlobNotFound,
+    BlobUploadUnknown,
     GatewayTimeout,
     InvalidRequest,
     ManifestInvalid,
@@ -1042,6 +1043,18 @@ def head(self, request, path, pk=None):
         """Respond to HEAD requests about blob uploads."""
         return self.get(request, path, pk=pk)
 
+    def destroy(self, request, path, pk=None):
+        """
+        Cancel an outstanding blob upload.
+        """
+        _, repository = self.get_dr_push(request, path)
+        try:
+            upload = models.Upload.objects.get(repository=repository, pk=pk)
+        except models.Upload.DoesNotExist:
+            raise BlobUploadUnknown(uuid=pk)
+        upload.delete()
+        return Response(status=204)
+
     def put(self, request, path, pk=None):
         """
         Create a blob from uploaded chunks.
diff --git a/pulp_container/tests/functional/api/test_cancel_blob_upload.py b/pulp_container/tests/functional/api/test_cancel_blob_upload.py
new file mode 100644
index 000000000..3f62b36d1
--- /dev/null
+++ b/pulp_container/tests/functional/api/test_cancel_blob_upload.py
@@ -0,0 +1,71 @@
+"""Tests for cancelling blob uploads via the Docker v2 API."""
+
+import uuid
+
+import pytest
+
+
+def _start_blob_upload(local_registry, full_path, repo_name):
+    upload_path = f"/v2/{full_path(repo_name)}/blobs/uploads/"
+    response, _ = local_registry.get_response("POST", upload_path)
+    assert response.status_code == 202
+    return response.headers["Docker-Upload-UUID"]
+
+
+class TestCancelBlobUpload:
+    """Tests for DELETE /v2/<name>/blobs/uploads/<uuid>."""
+
+    repo_name = "cancel/upload"
+
+    @pytest.fixture(scope="class")
+    def setup(
+        self,
+        add_to_cleanup,
+        container_bindings,
+        container_repository_factory,
+        container_distribution_factory,
+    ):
+        """Create a push repository and distribution for all cancel blob upload tests."""
+        repository = container_repository_factory()
+        distribution = container_distribution_factory(
+            name=self.repo_name,
+            base_path=self.repo_name,
+            repository=repository.pulp_href,
+        )
+        namespace = container_bindings.PulpContainerNamespacesApi.read(distribution.namespace)
+        add_to_cleanup(container_bindings.PulpContainerNamespacesApi, namespace.pulp_href)
+
+    def test_01_cancel_unknown_blob_upload(self, setup, local_registry, full_path):
+        """Cancelling a blob upload that does not exist returns 404."""
+        upload_uuid = uuid.uuid4()
+        delete_path = f"/v2/{full_path(self.repo_name)}/blobs/uploads/{upload_uuid}"
+        response, _ = local_registry.get_response("DELETE", delete_path)
+        assert response.status_code == 404
+        assert response.json()["errors"][0]["code"] == "BLOB_UPLOAD_UNKNOWN"
+
+    def test_02_cancel_blob_upload_without_permission(
+        self, setup, gen_user, local_registry, full_path
+    ):
+        """Cancel requires push permissions on the namespace."""
+        upload_uuid = _start_blob_upload(local_registry, full_path, self.repo_name)
+        delete_path = f"/v2/{full_path(self.repo_name)}/blobs/uploads/{upload_uuid}"
+        user_helpless = gen_user()
+        with user_helpless:
+            response, _ = local_registry.get_response("DELETE", delete_path)
+        assert response.status_code in (401, 403)
+
+    def test_03_cancel_blob_upload(self, setup, local_registry, full_path):
+        """Cancel an outstanding blob upload via DELETE /v2/<name>/blobs/uploads/<uuid>."""
+        upload_uuid = _start_blob_upload(local_registry, full_path, self.repo_name)
+        upload_path = f"/v2/{full_path(self.repo_name)}/blobs/uploads/{upload_uuid}"
+
+        response, _ = local_registry.get_response("GET", upload_path)
+        assert response.status_code == 204
+        assert response.headers["Docker-Upload-UUID"] == upload_uuid
+
+        response, _ = local_registry.get_response("DELETE", upload_path)
+        assert response.status_code == 204
+        assert response.content == b""
+
+        response, _ = local_registry.get_response("GET", upload_path)
+        assert response.status_code == 404