diff --git a/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.spec.tsx b/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.spec.tsx
index b9bc471acdc..0a27fb6c480 100644
--- a/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.spec.tsx
+++ b/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.spec.tsx
@@ -1,7 +1,7 @@
 import * as React from 'react';
 import { render, screen, fireEvent } from '@testing-library/react';
 
-import { Basic } from './InPlaceEditor.stories';
+import { Basic, WithSiblingControl } from './InPlaceEditor.stories';
 
 describe('InPlaceEditor', () => {
     it('should render the field value on mount', async () => {
@@ -54,4 +54,37 @@ describe('InPlaceEditor', () => {
             await screen.findByLabelText('Cancel');
         });
     });
+    describe('blur', () => {
+        it('should save when focus moves to a control outside the editor', async () => {
+            render(<WithSiblingControl />);
+            const value = await screen.findByText('John Doe');
+            value.click();
+            const input = await screen.findByDisplayValue('John Doe');
+            fireEvent.change(input, { target: { value: 'Jane Doe' } });
+            const nextButton = screen.getByRole('button', { name: 'Next' });
+            fireEvent.blur(input, { relatedTarget: nextButton });
+            await screen.findByText('Jane Doe');
+        });
+        it('should cancel when focus moves to a control outside the editor and cancelOnBlur is set', async () => {
+            render(<WithSiblingControl cancelOnBlur />);
+            const value = await screen.findByText('John Doe');
+            value.click();
+            const input = await screen.findByDisplayValue('John Doe');
+            fireEvent.change(input, { target: { value: 'Jane Doe' } });
+            const nextButton = screen.getByRole('button', { name: 'Next' });
+            fireEvent.blur(input, { relatedTarget: nextButton });
+            await screen.findByText('John Doe');
+            expect(screen.queryByDisplayValue('Jane Doe')).toBeNull();
+        });
+        it('should keep editing when focus moves to a button inside the editor', async () => {
+            render(<Basic delay={0} showButtons />);
+            const value = await screen.findByText('John Doe');
+            value.click();
+            const input = await screen.findByDisplayValue('John Doe');
+            fireEvent.change(input, { target: { value: 'Jane Doe' } });
+            const saveButton = screen.getByLabelText('Save');
+            fireEvent.blur(input, { relatedTarget: saveButton });
+            expect(screen.getByDisplayValue('Jane Doe')).not.toBeNull();
+        });
+    });
 });
diff --git a/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.stories.tsx b/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.stories.tsx
index 19ad352c879..ff2b420fb28 100644
--- a/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.stories.tsx
+++ b/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.stories.tsx
@@ -175,6 +175,21 @@ export const CancelOnBlur = () => (
     </Wrapper>
 );
 
+export const WithSiblingControl = ({
+    cancelOnBlur,
+}: {
+    cancelOnBlur?: boolean;
+}) => (
+    <Wrapper
+        dataProvider={fakeRestDataProvider({
+            users: [{ id: 1, name: 'John Doe', age: 25, type: 'customer' }],
+        })}
+    >
+        <InPlaceEditor source="name" cancelOnBlur={cancelOnBlur} />
+        <button type="button">Next</button>
+    </Wrapper>
+);
+
 export const MutationMode = () => (
     <Wrapper>
         <InPlaceEditor source="name" mutationMode="optimistic" />
diff --git a/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.tsx b/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.tsx
index d8756b61b12..4138e15c2a4 100644
--- a/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.tsx
+++ b/packages/ra-ui-materialui/src/input/InPlaceEditor/InPlaceEditor.tsx
@@ -196,7 +196,13 @@ export const InPlaceEditor = <
     };
 
     const handleBlur = (event: React.FocusEvent) => {
-        if (event.relatedTarget) {
+        // Keep editing when focus moves to another element inside the editor
+        // (e.g. the Save and Cancel buttons). Only save or cancel when focus
+        // leaves the editor entirely.
+        if (
+            event.relatedTarget &&
+            event.currentTarget.contains(event.relatedTarget as Node)
+        ) {
             return;
         }
         if (cancelOnBlur) {