diff --git a/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/dataloader/route.ts b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/dataloader/route.ts
new file mode 100644
index 000000000000..00ae43a3cf4c
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/dataloader/route.ts
@@ -0,0 +1,15 @@
+import DataLoader from 'dataloader';
+import { NextResponse } from 'next/server';
+
+export const dynamic = 'force-dynamic';
+
+export async function GET() {
+  const loader = new DataLoader<string, number>(async keys => keys.map((_, idx) => idx), {
+    cache: false,
+    name: 'usersLoader',
+  });
+
+  const user = await loader.load('user-1');
+
+  return NextResponse.json({ user });
+}
diff --git a/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/generic-pool/route.ts b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/generic-pool/route.ts
new file mode 100644
index 000000000000..01c190c29997
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/generic-pool/route.ts
@@ -0,0 +1,37 @@
+import { createPool } from 'generic-pool';
+import { NextResponse } from 'next/server';
+import { Client } from 'pg';
+
+export const dynamic = 'force-dynamic';
+
+export async function GET() {
+  const pool = createPool(
+    {
+      create: async () => {
+        const client = new Client({
+          host: 'localhost',
+          port: 5432,
+          user: 'postgres',
+          password: 'docker',
+          database: 'postgres',
+        });
+        await client.connect();
+        return client;
+      },
+      destroy: async client => {
+        await client.end();
+      },
+    },
+    { max: 2, min: 0 },
+  );
+
+  try {
+    const client = await pool.acquire();
+    await client.query('SELECT 1 + 1 AS solution');
+    await pool.release(client);
+    return NextResponse.json({ status: 'ok' });
+  } finally {
+    await pool.drain();
+    await pool.clear();
+  }
+}
diff --git a/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/knex/route.ts b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/knex/route.ts
new file mode 100644
index 000000000000..ff3ddb017607
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/knex/route.ts
@@ -0,0 +1,33 @@
+import knex from 'knex';
+import { NextResponse } from 'next/server';
+
+export const dynamic = 'force-dynamic';
+
+export async function GET() {
+  const db = knex({
+    client: 'pg',
+    connection: {
+      host: 'localhost',
+      port: 5432,
+      user: 'postgres',
+      password: 'docker',
+      database: 'postgres',
+    },
+  });
+
+  try {
+    await db.schema.dropTableIfExists('knex_users');
+    await db.schema.createTable('knex_users', table => {
+      table.increments('id').primary();
+      table.text('name').notNullable();
+    });
+
+    await db('knex_users').insert({ name: 'bob' });
+    await db('knex_users').select('*');
+
+    return NextResponse.json({ status: 'ok' });
+  } finally {
+    await db.schema.dropTableIfExists('knex_users');
+    await db.destroy();
+  }
+}
diff --git a/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/lru-memoizer/route.ts b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/lru-memoizer/route.ts
new file mode 100644
index 000000000000..3e9a89409c43
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/app/api/lru-memoizer/route.ts
@@ -0,0 +1,48 @@
+import * as Sentry from '@sentry/nextjs';
+import memoizer from 'lru-memoizer';
+import { NextResponse } from 'next/server';
+
+export const dynamic = 'force-dynamic';
+
+// lru-memoizer's only job (from the SDK's perspective) is to bind the active async context onto the
+// memoized callback, so it runs in its originating span's context whenever the load resolves. The
+// integration creates no spans — we assert the context restore instead.
+//
+// `load` captures its callback without resolving. We register the memoized call INSIDE the
+// `lru-memoizer-check` span (so orchestrion captures that span as the context to restore), but fire
+// the load AFTER `startSpan` returns — i.e. outside the span's active context. That's essential: if
+// we fired it inside the span, the callback would see the span through normal async propagation and
+// the assertion would pass even with orchestrion's context restore broken. Firing it outside means
+// only the restore can make the callback observe the span. Mirrors the node lru-memoizer test.
+export async function GET() {
+  let memoizerLoadCallback: (() => void) | undefined;
+  const memoizedFn = memoizer({
+    load: (_param: unknown, callback: () => void) => {
+      memoizerLoadCallback = callback;
+    },
+    hash: () => 'key',
+  });
+
+  // `startSpan` invokes its callback synchronously, so `memoizerLoadCallback` is captured by the time
+  // it returns. We don't await here — the callback only fires once the load below runs.
+  const spanFinished = Sentry.startSpan(
+    { name: 'lru-memoizer-check', op: 'run' },
+    span =>
+      new Promise<void>(resolve => {
+        memoizedFn({ foo: 'bar' }, () => {
+          span.setAttribute(
+            'memoized.context_preserved',
+            Sentry.getActiveSpan()?.spanContext().spanId === span.spanContext().spanId,
+          );
+          resolve();
+        });
+      }),
+  );
+
+  // Fire the load outside the span's context, so the assertion above proves the context was restored.
+  memoizerLoadCallback?.();
+
+  await spanFinished;
+
+  return NextResponse.json({ status: 'ok' });
+}
diff --git a/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/package.json b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/package.json
index 71bf2b466f1f..c697f2daeda8 100644
--- a/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/package.json
+++ b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/package.json
@@ -18,7 +18,11 @@
   "dependencies": {
     "@sentry/core": "file:../../packed/sentry-core-packed.tgz",
     "@sentry/nextjs": "file:../../packed/sentry-nextjs-packed.tgz",
+    "dataloader": "2.2.2",
+    "generic-pool": "^3.9.0",
     "ioredis": "5.10.1",
+    "knex": "^2.5.1",
+    "lru-memoizer": "2.3.0",
     "mysql": "^2.18.1",
     "next": "16.2.10",
     "pg": "^8.13.1",
diff --git a/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/sentry.server.config.ts b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/sentry.server.config.ts
index 085ed461ee07..c19e88472ae5 100644
--- a/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/sentry.server.config.ts
+++ b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/sentry.server.config.ts
@@ -12,4 +12,7 @@ Sentry.init({
   dsn: 'https://public@dsn.ingest.sentry.io/1337',
   tunnel: 'http://localhost:3031/', // proxy server
   tracesSampleRate: 1.0,
+  // `generic-pool` and `lru-memoizer` are default integrations, but `dataloader` and `knex` are
+  // opt-in, so they must be added explicitly for their orchestrion channel subscribers to activate.
+  integrations: [Sentry.dataloaderIntegration(), Sentry.knexIntegration()],
 });
diff --git a/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/tests/instrumentations.test.ts b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/tests/instrumentations.test.ts
new file mode 100644
index 000000000000..00029800a5c3
--- /dev/null
+++ b/dev-packages/e2e-tests/test-applications/nextjs-16-orchestrion/tests/instrumentations.test.ts
@@ -0,0 +1,126 @@
+import { expect, test } from '@playwright/test';
+import { waitForTransaction } from '@sentry-internal/test-utils';
+
+test('Instruments generic-pool automatically via orchestrion', async ({ baseURL }) => {
+  const transactionEventPromise = waitForTransaction('nextjs-16-orchestrion', transactionEvent => {
+    return (
+      transactionEvent.contexts?.trace?.op === 'http.server' && transactionEvent.transaction === 'GET /api/generic-pool'
+    );
+  });
+
+  await fetch(`${baseURL}/api/generic-pool`);
+
+  const transactionEvent = await transactionEventPromise;
+
+  const spans = transactionEvent.spans || [];
+
+  expect(spans).toContainEqual(
+    expect.objectContaining({
+      description: 'generic-pool.acquire',
+      origin: 'auto.db.orchestrion.generic_pool',
+      status: 'ok',
+      data: expect.objectContaining({
+        'sentry.origin': 'auto.db.orchestrion.generic_pool',
+      }),
+    }),
+  );
+});
+
+test('Instruments dataloader automatically via orchestrion', async ({ baseURL }) => {
+  const transactionEventPromise = waitForTransaction('nextjs-16-orchestrion', transactionEvent => {
+    return (
+      transactionEvent.contexts?.trace?.op === 'http.server' && transactionEvent.transaction === 'GET /api/dataloader'
+    );
+  });
+
+  await fetch(`${baseURL}/api/dataloader`);
+
+  const transactionEvent = await transactionEventPromise;
+
+  const spans = transactionEvent.spans || [];
+
+  const loadSpan = spans.find(span => span.description === 'dataloader.load usersLoader');
+  expect(loadSpan).toBeDefined();
+  expect(loadSpan?.op).toBe('cache.get');
+  expect(loadSpan?.origin).toBe('auto.db.orchestrion.dataloader');
+  expect(loadSpan?.status).toBe('ok');
+  expect(loadSpan?.data?.['cache.key']).toEqual(['user-1']);
+
+  // The batch span opens on the deferred dispatch tick and links back to the load span.
+  const batchSpan = spans.find(span => span.description === 'dataloader.batch usersLoader');
+  expect(batchSpan).toBeDefined();
+  expect(batchSpan?.op).toBe('cache.get');
+  expect(batchSpan?.origin).toBe('auto.db.orchestrion.dataloader');
+  expect(batchSpan?.status).toBe('ok');
+});
+
+test('Instruments knex automatically via orchestrion', async ({ baseURL }) => {
+  const transactionEventPromise = waitForTransaction('nextjs-16-orchestrion', transactionEvent => {
+    return transactionEvent.contexts?.trace?.op === 'http.server' && transactionEvent.transaction === 'GET /api/knex';
+  });
+
+  await fetch(`${baseURL}/api/knex`);
+
+  const transactionEvent = await transactionEventPromise;
+
+  const spans = transactionEvent.spans || [];
+
+  expect(spans).toContainEqual(
+    expect.objectContaining({
+      op: 'db',
+      origin: 'auto.db.orchestrion.knex',
+      status: 'ok',
+      description: 'insert into "knex_users" ("name") values (?)',
+      data: expect.objectContaining({
+        'db.system': 'postgresql',
+        'db.name': 'postgres',
+        'sentry.origin': 'auto.db.orchestrion.knex',
+        'sentry.op': 'db',
+        'net.peer.name': 'localhost',
+        'net.peer.port': 5432,
+      }),
+    }),
+  );
+  expect(spans).toContainEqual(
+    expect.objectContaining({
+      op: 'db',
+      origin: 'auto.db.orchestrion.knex',
+      status: 'ok',
+      description: 'select * from "knex_users"',
+      data: expect.objectContaining({
+        'db.system': 'postgresql',
+        'db.operation': 'select',
+        'db.sql.table': 'knex_users',
+        'db.statement': 'select * from "knex_users"',
+        'sentry.origin': 'auto.db.orchestrion.knex',
+        'sentry.op': 'db',
+      }),
+    }),
+  );
+});
+
+// lru-memoizer's channel integration creates no spans — its only job is to restore the caller's async
+// context onto the memoized callback. The route wraps the check in a `lru-memoizer-check` span and
+// records whether the callback ran in that span's context, so we assert the attribute on that span.
+test('Preserves async context through lru-memoizer via orchestrion', async ({ baseURL }) => {
+  const transactionEventPromise = waitForTransaction('nextjs-16-orchestrion', transactionEvent => {
+    return (
+      transactionEvent.contexts?.trace?.op === 'http.server' && transactionEvent.transaction === 'GET /api/lru-memoizer'
+    );
+  });
+
+  await fetch(`${baseURL}/api/lru-memoizer`);
+
+  const transactionEvent = await transactionEventPromise;
+
+  const spans = transactionEvent.spans || [];
+
+  expect(spans).toContainEqual(
+    expect.objectContaining({
+      description: 'lru-memoizer-check',
+      data: expect.objectContaining({
+        'memoized.context_preserved': true,
+      }),
+    }),
+  );
+});