diff --git a/dev-packages/deno-integration-tests/suites/orchestrion-anthropic/test.ts b/dev-packages/deno-integration-tests/suites/orchestrion-anthropic/test.ts
new file mode 100644
index 000000000000..f03d7450c6cb
--- /dev/null
+++ b/dev-packages/deno-integration-tests/suites/orchestrion-anthropic/test.ts
@@ -0,0 +1,105 @@
+// <reference lib="deno.ns" />
+
+import { tracingChannel } from 'node:diagnostics_channel';
+import type { TransactionEvent } from '@sentry/core';
+import type { DenoClient } from '@sentry/deno';
+import { getCurrentScope, getGlobalScope, getIsolationScope, init, startSpan } from '@sentry/deno';
+import { assert } from 'https://deno.land/std@0.212.0/assert/assert.ts';
+import { assertExists } from 'https://deno.land/std@0.212.0/assert/assert_exists.ts';
+import { assertEquals } from 'https://deno.land/std@0.212.0/assert/assert_equals.ts';
+
+function resetGlobals(): void {
+  getCurrentScope().clear();
+  getCurrentScope().setClient(undefined);
+  getIsolationScope().clear();
+  getGlobalScope().clear();
+}
+
+/** See deno-redis.test.ts — same sink shape, deduped for clarity. */
+function transactionSink(): {
+  beforeSendTransaction: (event: TransactionEvent) => null;
+  waitFor: (predicate: (event: TransactionEvent) => boolean) => Promise<TransactionEvent>;
+} {
+  const transactions: TransactionEvent[] = [];
+  const waiters: { predicate: (e: TransactionEvent) => boolean; resolve: (e: TransactionEvent) => void }[] = [];
+  return {
+    beforeSendTransaction(event) {
+      transactions.push(event);
+      for (let i = waiters.length - 1; i >= 0; i--) {
+        const w = waiters[i]!;
+        if (w.predicate(event)) {
+          waiters.splice(i, 1);
+          w.resolve(event);
+        }
+      }
+      return null;
+    },
+    waitFor(predicate) {
+      const already = transactions.find(predicate);
+      if (already) return Promise.resolve(already);
+      return new Promise<TransactionEvent>(resolve => {
+        waiters.push({ predicate, resolve });
+      });
+    },
+  };
+}
+
+function withTimeout<T>(p: Promise<T>, ms: number, what: string): Promise<T> {
+  let timer: ReturnType<typeof setTimeout> | undefined;
+  const timeout = new Promise<T>((_, reject) => {
+    timer = setTimeout(() => reject(new Error(`Timed out waiting for ${what} after ${ms}ms`)), ms);
+  });
+  return Promise.race([p, timeout]).finally(() => {
+    if (timer !== undefined) clearTimeout(timer);
+  });
+}
+
+Deno.test('anthropic instrumentation: included in default integrations (Deno 2.8.0+)', () => {
+  resetGlobals();
+  const client = init({ dsn: 'https://username@domain/123' }) as DenoClient;
+  const names = client.getOptions().integrations.map(i => i.name);
+  assert(names.includes('Anthropic_AI'), `Anthropic_AI should be in defaults, got ${names.join(', ')}`);
+});
+
+Deno.test('anthropic instrumentation: orchestrion @anthropic-ai/sdk:chat channel produces a nested gen_ai span', async () => {
+  resetGlobals();
+  const sink = transactionSink();
+  init({
+    dsn: 'https://username@domain/123',
+    tracesSampleRate: 1,
+    beforeSendTransaction: sink.beforeSendTransaction,
+  });
+
+  const channel = tracingChannel('orchestrion:@anthropic-ai/sdk:chat');
+
+  // `arguments[0]` is the request body passed to `messages.create(body, options)`.
+  const body = { model: 'claude-3-5-sonnet-latest', messages: [{ role: 'user', content: 'hi' }] };
+  const ctx: Record<string, unknown> = { arguments: [body] };
+
+  startSpan({ name: 'parent', op: 'test' }, () => {
+    channel.start.runStores(ctx, () => undefined);
+    channel.end.publish(ctx);
+    ctx.result = {
+      id: 'msg_1',
+      model: 'claude-3-5-sonnet-20241022',
+      usage: { input_tokens: 10, output_tokens: 5 },
+    };
+    channel.asyncEnd.publish(ctx);
+  });
+
+  const parent = await withTimeout(
+    sink.waitFor(t => t.transaction === 'parent'),
+    5000,
+    "'parent' transaction",
+  );
+
+  const aiSpan = parent.spans?.find(s => s.op === 'gen_ai.chat');
+  assertExists(aiSpan, `expected a gen_ai.chat child span, got ops: ${parent.spans?.map(s => s.op).join(', ')}`);
+  assertEquals(aiSpan!.description, 'chat claude-3-5-sonnet-latest');
+  assertEquals(aiSpan!.data?.['gen_ai.system'], 'anthropic');
+  assertEquals(aiSpan!.data?.['gen_ai.operation.name'], 'chat');
+  assertEquals(aiSpan!.data?.['gen_ai.request.model'], 'claude-3-5-sonnet-latest');
+  assertEquals(aiSpan!.data?.['gen_ai.response.model'], 'claude-3-5-sonnet-20241022');
+  assertEquals(aiSpan!.data?.['gen_ai.usage.total_tokens'], 15);
+  assertEquals(aiSpan!.data?.['sentry.origin'], 'auto.ai.orchestrion.anthropic');
+});
diff --git a/packages/deno/src/index.ts b/packages/deno/src/index.ts
index 17479fb46b63..6fafb47a4d0e 100644
--- a/packages/deno/src/index.ts
+++ b/packages/deno/src/index.ts
@@ -117,6 +117,7 @@ export type { DenoRedisIntegrationOptions } from './integrations/redis';
 // adds to the defaults, so users who customize `defaultIntegrations` can re-add it.
 export {
   amqplibChannelIntegration,
+  anthropicChannelIntegration,
   awsChannelIntegration,
   dataloaderChannelIntegration,
   expressChannelIntegration,
diff --git a/packages/deno/src/sdk.ts b/packages/deno/src/sdk.ts
index 3101786c6337..e4b79978dad0 100644
--- a/packages/deno/src/sdk.ts
+++ b/packages/deno/src/sdk.ts
@@ -13,6 +13,7 @@ import {
 } from '@sentry/core';
 import {
   amqplibChannelIntegration,
+  anthropicChannelIntegration,
   awsChannelIntegration,
   expressChannelIntegration,
   firebaseChannelIntegration,
@@ -89,6 +90,7 @@ export function getDefaultIntegrations(_options: Options): Integration[] {
     ...(MODULE_REGISTER_HOOKS_SUPPORTED
       ? [
           amqplibChannelIntegration(),
+          anthropicChannelIntegration(),
           awsChannelIntegration(),
           expressChannelIntegration(),
           firebaseChannelIntegration(),
diff --git a/packages/deno/test/__snapshots__/mod.test.ts.snap b/packages/deno/test/__snapshots__/mod.test.ts.snap
index e831e0d8995c..83ea2aeb046d 100644
--- a/packages/deno/test/__snapshots__/mod.test.ts.snap
+++ b/packages/deno/test/__snapshots__/mod.test.ts.snap
@@ -117,6 +117,7 @@ snapshot[`captureException 1`] = `
       "DenoRedis",
       "Graphql",
       "Amqplib",
+      "Anthropic_AI",
       "Aws",
       "Express",
       "Firebase",
@@ -210,6 +211,7 @@ snapshot[`captureMessage 1`] = `
       "DenoRedis",
       "Graphql",
       "Amqplib",
+      "Anthropic_AI",
       "Aws",
       "Express",
       "Firebase",
@@ -310,6 +312,7 @@ snapshot[`captureMessage twice 1`] = `
       "DenoRedis",
       "Graphql",
       "Amqplib",
+      "Anthropic_AI",
       "Aws",
       "Express",
       "Firebase",
@@ -417,6 +420,7 @@ snapshot[`captureMessage twice 2`] = `
       "DenoRedis",
       "Graphql",
       "Amqplib",
+      "Anthropic_AI",
       "Aws",
       "Express",
       "Firebase",