diff --git a/dev-packages/deno-integration-tests/suites/orchestrion-mysql2/test.ts b/dev-packages/deno-integration-tests/suites/orchestrion-mysql2/test.ts
new file mode 100644
index 000000000000..b0aef546de46
--- /dev/null
+++ b/dev-packages/deno-integration-tests/suites/orchestrion-mysql2/test.ts
@@ -0,0 +1,106 @@
+// <reference lib="deno.ns" />
+
+import { tracingChannel } from 'node:diagnostics_channel';
+import type { TransactionEvent } from '@sentry/core';
+import type { DenoClient } from '@sentry/deno';
+import { getCurrentScope, getGlobalScope, getIsolationScope, init, startSpan } from '@sentry/deno';
+import { assert } from 'https://deno.land/std@0.212.0/assert/assert.ts';
+import { assertEquals } from 'https://deno.land/std@0.212.0/assert/assert_equals.ts';
+import { assertExists } from 'https://deno.land/std@0.212.0/assert/assert_exists.ts';
+
+function resetGlobals(): void {
+  getCurrentScope().clear();
+  getCurrentScope().setClient(undefined);
+  getIsolationScope().clear();
+  getGlobalScope().clear();
+}
+
+/** See deno-redis.test.ts — same sink shape, deduped for clarity. */
+function transactionSink(): {
+  beforeSendTransaction: (event: TransactionEvent) => null;
+  waitFor: (predicate: (event: TransactionEvent) => boolean) => Promise<TransactionEvent>;
+} {
+  const transactions: TransactionEvent[] = [];
+  const waiters: { predicate: (e: TransactionEvent) => boolean; resolve: (e: TransactionEvent) => void }[] = [];
+  return {
+    beforeSendTransaction(event) {
+      transactions.push(event);
+      for (let i = waiters.length - 1; i >= 0; i--) {
+        const w = waiters[i]!;
+        if (w.predicate(event)) {
+          waiters.splice(i, 1);
+          w.resolve(event);
+        }
+      }
+      return null;
+    },
+    waitFor(predicate) {
+      const already = transactions.find(predicate);
+      if (already) return Promise.resolve(already);
+      return new Promise<TransactionEvent>(resolve => {
+        waiters.push({ predicate, resolve });
+      });
+    },
+  };
+}
+
+function withTimeout<T>(p: Promise<T>, ms: number, what: string): Promise<T> {
+  let timer: ReturnType<typeof setTimeout> | undefined;
+  const timeout = new Promise<T>((_, reject) => {
+    timer = setTimeout(() => reject(new Error(`Timed out waiting for ${what} after ${ms}ms`)), ms);
+  });
+  return Promise.race([p, timeout]).finally(() => {
+    if (timer !== undefined) clearTimeout(timer);
+  });
+}
+
+Deno.test('mysql2 instrumentation: included in default integrations (Deno 2.8.0+)', () => {
+  resetGlobals();
+  const client = init({ dsn: 'https://username@domain/123' }) as DenoClient;
+  const names = client.getOptions().integrations.map(i => i.name);
+  assert(names.includes('Mysql2'), `Mysql2 should be in defaults, got ${names.join(', ')}`);
+});
+
+Deno.test('mysql2 instrumentation: orchestrion:mysql2:query channel produces a nested db span', async () => {
+  resetGlobals();
+  const sink = transactionSink();
+  init({
+    dsn: 'https://username@domain/123',
+    tracesSampleRate: 1,
+    beforeSendTransaction: sink.beforeSendTransaction,
+  });
+
+  const channel = tracingChannel('orchestrion:mysql2:query');
+
+  // `arguments[0]` is the SQL; `self.config` is the mysql2 connection config.
+  const ctx = {
+    arguments: ['SELECT 1 AS solution'],
+    self: { config: { host: '127.0.0.1', port: 3306, database: 'mydb', user: 'root' } },
+  };
+
+  startSpan({ name: 'parent', op: 'test' }, () => {
+    channel.start.runStores(ctx, () => {
+      channel.end.publish(ctx);
+    });
+    channel.asyncStart.runStores(ctx, () => {
+      channel.asyncEnd.publish(ctx);
+    });
+  });
+
+  const parent = await withTimeout(
+    sink.waitFor(t => t.transaction === 'parent'),
+    5000,
+    "'parent' transaction",
+  );
+
+  const mysqlSpan = parent.spans?.find(s => s.op === 'db');
+  assertExists(mysqlSpan, `expected a db child span, got ops: ${parent.spans?.map(s => s.op).join(', ')}`);
+  assertEquals(mysqlSpan!.description, 'SELECT 1 AS solution');
+  assertEquals(mysqlSpan!.data?.['db.system'], 'mysql');
+  assertEquals(mysqlSpan!.data?.['db.statement'], 'SELECT 1 AS solution');
+  assertEquals(mysqlSpan!.data?.['db.name'], 'mydb');
+  assertEquals(mysqlSpan!.data?.['db.user'], 'root');
+  assertEquals(mysqlSpan!.data?.['net.peer.name'], '127.0.0.1');
+  assertEquals(mysqlSpan!.data?.['net.peer.port'], 3306);
+  assertEquals(mysqlSpan!.data?.['sentry.origin'], 'auto.db.orchestrion.mysql2');
+});
diff --git a/packages/deno/src/index.ts b/packages/deno/src/index.ts
index 2be88c84c751..3d3ef7fa10f9 100644
--- a/packages/deno/src/index.ts
+++ b/packages/deno/src/index.ts
@@ -123,6 +123,7 @@ export {
   mongodbChannelIntegration,
   mongooseChannelIntegration,
   mysqlChannelIntegration,
+  mysql2ChannelIntegration,
   postgresChannelIntegration,
   postgresJsChannelIntegration,
 } from '@sentry/server-utils/orchestrion';
diff --git a/packages/deno/src/sdk.ts b/packages/deno/src/sdk.ts
index 77a241a57a89..e3ec76137b43 100644
--- a/packages/deno/src/sdk.ts
+++ b/packages/deno/src/sdk.ts
@@ -17,6 +17,7 @@ import {
   mongodbChannelIntegration,
   mongooseChannelIntegration,
   mysqlChannelIntegration,
+  mysql2ChannelIntegration,
   postgresChannelIntegration,
   postgresJsChannelIntegration,
 } from '@sentry/server-utils/orchestrion';
@@ -77,6 +78,7 @@ export function getDefaultIntegrations(_options: Options): Integration[] {
           mongodbChannelIntegration(),
           mongooseChannelIntegration(),
           mysqlChannelIntegration(),
+          mysql2ChannelIntegration(),
           postgresChannelIntegration(),
           postgresJsChannelIntegration(),
         ]
diff --git a/packages/deno/test/__snapshots__/mod.test.ts.snap b/packages/deno/test/__snapshots__/mod.test.ts.snap
index 8fb952298f27..e110dcb09e6c 100644
--- a/packages/deno/test/__snapshots__/mod.test.ts.snap
+++ b/packages/deno/test/__snapshots__/mod.test.ts.snap
@@ -120,6 +120,7 @@ snapshot[`captureException 1`] = `
       "Mongo",
       "Mongoose",
       "Mysql",
+      "Mysql2",
       "Postgres",
       "PostgresJs",
       "ContextLines",
@@ -202,6 +203,7 @@ snapshot[`captureMessage 1`] = `
       "Mongo",
       "Mongoose",
       "Mysql",
+      "Mysql2",
       "Postgres",
       "PostgresJs",
       "ContextLines",
@@ -291,6 +293,7 @@ snapshot[`captureMessage twice 1`] = `
       "Mongo",
       "Mongoose",
       "Mysql",
+      "Mysql2",
       "Postgres",
       "PostgresJs",
       "ContextLines",
@@ -387,6 +390,7 @@ snapshot[`captureMessage twice 2`] = `
       "Mongo",
       "Mongoose",
       "Mysql",
+      "Mysql2",
       "Postgres",
       "PostgresJs",
       "ContextLines",