diff --git a/packages/react-dom-bindings/src/server/ReactFizzConfigDOM.js b/packages/react-dom-bindings/src/server/ReactFizzConfigDOM.js
index 73ce8d3dd29f..f3c83c8085ff 100644
--- a/packages/react-dom-bindings/src/server/ReactFizzConfigDOM.js
+++ b/packages/react-dom-bindings/src/server/ReactFizzConfigDOM.js
@@ -3017,6 +3017,66 @@ function pushLink(
       // them up when the primary content is ready. They are never hydrated on the client anyway because
       // boundaries in fallback are awaited or client render, in either case there is never hydration
       return null;
+    } else if (rel === 'preload') {
+      // Preload links can be deduplicated against preloads initiated via the
+      // imperative preload() API or received as Flight hints. We check and
+      // register in resumableState to avoid duplicate link tags.
+      const as = props.as;
+      if (typeof as === 'string') {
+        switch (as) {
+          case 'image': {
+            const imageSrcSet =
+              typeof props.imageSrcSet === 'string'
+                ? props.imageSrcSet
+                : undefined;
+            const imageSizes =
+              typeof props.imageSizes === 'string'
+                ? props.imageSizes
+                : undefined;
+            const key = getImageResourceKey(href, imageSrcSet, imageSizes);
+            if (resumableState.imageResources.hasOwnProperty(key)) {
+              return null;
+            }
+            resumableState.imageResources[key] = PRELOAD_NO_CREDS;
+            break;
+          }
+          case 'style': {
+            const key = getResourceKey(href);
+            if (resumableState.styleResources.hasOwnProperty(key)) {
+              return null;
+            }
+            resumableState.styleResources[key] = PRELOAD_NO_CREDS;
+            break;
+          }
+          case 'script': {
+            const key = getResourceKey(href);
+            if (resumableState.scriptResources.hasOwnProperty(key)) {
+              return null;
+            }
+            resumableState.scriptResources[key] = PRELOAD_NO_CREDS;
+            break;
+          }
+          default: {
+            // font, audio, video, document, embed, fetch, object, track, worker, and others
+            const key = getResourceKey(href);
+            const hasAsType =
+              resumableState.unknownResources.hasOwnProperty(as);
+            let resources;
+            if (hasAsType) {
+              resources = resumableState.unknownResources[as];
+              if (resources.hasOwnProperty(key)) {
+                return null;
+              }
+            } else {
+              resources = ({}: ResumableState['unknownResources']['asType']);
+              resumableState.unknownResources[as] = resources;
+            }
+            resources[key] = PRELOAD_NO_CREDS;
+            break;
+          }
+        }
+      }
+      return pushLinkImpl(renderState.hoistableChunks, props);
     } else {
       return pushLinkImpl(renderState.hoistableChunks, props);
     }
diff --git a/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOM-test.js b/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOM-test.js
index 4abc18843050..929a54e74e5a 100644
--- a/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOM-test.js
+++ b/packages/react-server-dom-webpack/src/__tests__/ReactFlightDOM-test.js
@@ -2166,6 +2166,70 @@ describe('ReactFlightDOM', () => {
     );
   });
 
+  it('does not emit duplicate preload links in SSR when Flight hints preload a resource that is also rendered as JSX', async () => {
+    function Component() {
+      return <p>hello world</p>;
+    }
+
+    const ClientComponent = clientExports(Component);
+
+    function ServerComponent() {
+      return (
+        <div>
+          <link
+            rel="preload"
+            href="/font.woff2"
+            as="font"
+            type="font/woff2"
+            crossOrigin="anonymous"
+          />
+          <ClientComponent />
+        </div>
+      );
+    }
+
+    const {writable: flightWritable, readable: flightReadable} =
+      getTestStream();
+    const {writable: fizzWritable, readable: fizzReadable} = getTestStream();
+
+    const {pipe} = await serverAct(() =>
+      ReactServerDOMServer.renderToPipeableStream(
+        <ServerComponent />,
+        webpackMap,
+      ),
+    );
+    pipe(flightWritable);
+
+    let response = null;
+    function getResponse() {
+      if (response === null) {
+        response =
+          ReactServerDOMClient.createFromReadableStream(flightReadable);
+      }
+      return response;
+    }
+
+    function App() {
+      return (
+        <html>
+          <body>{getResponse()}</body>
+        </html>
+      );
+    }
+
+    await serverAct(async () => {
+      ReactDOMFizzServer.renderToPipeableStream(<App />).pipe(fizzWritable);
+    });
+
+    await readInto(document, fizzReadable);
+
+    // The font preload should appear only once, not twice
+    const preloadLinks = document.querySelectorAll(
+      'link[rel="preload"][as="font"]',
+    );
+    expect(preloadLinks.length).toBe(1);
+  });
+
   it('should be able to include a client reference in printed errors', async () => {
     const reportedErrors = [];