From 11430f176bd69b2a87dc6768d793bdcaff3719a6 Mon Sep 17 00:00:00 2001 From: Andrew Freiburger Date: Fri, 2 Oct 2026 09:32:41 -0500 Subject: [PATCH] NAR 2026: sync M14_discussion.tex with Overleaf edits Co-Authored-By: Claude Opus 5.5 (1M context) --- Papers/NAR_Update_2026/latex/sections/M14_discussion.tex | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/Papers/NAR_Update_2026/latex/sections/M14_discussion.tex b/Papers/NAR_Update_2026/latex/sections/M14_discussion.tex index e809f663..7cca2380 100644 --- a/Papers/NAR_Update_2026/latex/sections/M14_discussion.tex +++ b/Papers/NAR_Update_2026/latex/sections/M14_discussion.tex @@ -1,3 +1,5 @@ \section{Discussion} -Unlike the 2020 release, this update adopts a multi-source policy rather than promoting a single thermodynamic value, publishing four sources, each with their own uncertainty and estimated direction, because the sources may disagree in ways a single value conceals. Grading against experiment enables us to validate the approach: A researcher can take the highest-graded source and knows what the grade means. In being explicit about disagreement between sources, we expect this release to serve the widening range of communities that build on shared biochemistry: genome-scale reconstruction, flux analysis, pathway design and the training of predictive models. \ No newline at end of file +Unlike the 2020 release, this update integrates four thermodynamics sources, each with their own uncertainty and estimated direction, and a layered scheme to arrive at a predicted direction where sources disagree in ways a single source conceals. +We further leverage experimental ground truth data to validate our grading of the recommended direction. +In being explicit about disagreement between sources, we expect this release to serve the widening range of researchers who build on shared biochemistry: genome-scale reconstruction, flux analysis, pathway design and the training of predictive models. \ No newline at end of file