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title: 'DisProt 2026_06 - New thematic dataset of Stress response proteins'
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date: 2026-06-06 09:00:00 +0200
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date: 2026-07-01 09:00:00 +0200
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author: "Maria Cristina Aspromonte"
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The dataset includes proteins involved in heat shock responses, stress signaling, transcriptional regulation, protein quality control, and environmental adaptation. Together, these proteins show that intrinsic disorder is a conserved strategy used by cells to respond to stress across evolution.
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# Overview of the dataset
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- 142 curated proteins
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- 2629 different organisms
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- 176 curated publications
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- Proteins involved in heat shock response, oxidative stress, integrated stress response, and plant stress adaptation
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- 127 curated proteins
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- 28 different organisms
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- 223 curated publications
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Proteins involved in heat shock response, oxidative stress, integrated stress response, and plant stress adaptation
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# Examples of disordered stress-response proteins
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The newly curated functional annotations show that IDRs mediate self-interaction, which is important for oligomer formation, and 14-3-3 protein binding, an interaction involved in stress-related signaling pathways.
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